Production of uniform poly-lactic acid beads

Poly-lactic acid (PLA) microbeads with spherical shape having a diameter around 550 µm were produced using a three-step process. Firstly, uniform PLA droplets (dissolved in DCM) were stabilized in a calcium-alginate shell, the PLA microspheres were recovered by dissolution of the alginate shell in tri-sodium citrate solution.
Active pharmaceutical ingredients (APIs) could be embedded in the PLA matrix to extend the shelf live, increase the bioavailability as well as retarding its release.

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