Quantitation of acetylsalicylic acid, salicylic acid, and salicylic amide by HPTLC

Salicylic acid derivatives are contained in antipyretic, anti-inflammatory and analgesic drugs. Salicylic acid may be present as degradation product. It is also used as topical keratolytic.
The method is suitable for quantitation of actives in pharmaceutical products, detection of impurities as result of degradation and identification of unknown substances. Identification is based om Rf-values and spectral parameters; quantitation is performed by densitometry at 200 nm.

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