Lyovapor™ L-210

Technical specifications

• Lowest condenser temperature: −55 °C
• Condensing capacity: up to 6 kg/24 h, with a total condenser capacity of up to 6 kg
• Vacuum: minimum system vacuum of 0.03 mbar; controlled range from 0.1 to 1 mbar
• Drying configurations: manifold racks with 12 or 24 connections, non-heatable or heatable shelves, stoppering options and Frontloader configurations
• Process control: pressure-based endpoint determination on Basic configurations; pressure- and temperature-based endpoint determination, method programming and shelf heating up to 60 ±1 °C on Pro configurations

Model comparison overview

Lyovapor™ L-210 Basic

• Manifold racks or non-heatable shelves
• No vacuum control or advanced vacuum control
• Pressure-based endpoint determination
• Optional stoppering

Lyovapor™ L-210 Basic Defrosting

• Same drying and control options as the Basic configuration
• Hot-gas defrosting for manifold drying chambers

Lyovapor™ L-210 Pro

• Advanced vacuum control
• Heatable shelves with a maximum set temperature of 60 °C
• Pressure- and temperature-based endpoint determination
• Method programming and optional sample temperature sensor
• Optional stoppering

Lyovapor™ L-210 Pro Defrosting

• Same process-control and shelf-heating functions as the Pro configuration
• Hot-gas defrosting

The Lyovapor™ L-210 is a modular laboratory freeze dryer designed to remove frozen solvent from temperature-sensitive samples under vacuum. Its EcoStream™ refrigeration system reaches a condenser temperature of −55 °C and uses natural refrigerants with a global warming potential (GWP) of 3. The condenser can collect up to 6 kg of ice and provides a condensing capacity of up to 6 kg within 24 hours, making the system suitable for both small sample batches and larger water-based loads.

The instrument can be configured for flask, vial, tray, bulk-sample and multiwell-plate workflows. Drying attachments range from manifold racks and top-mounted chambers to the front-opening Frontloader. Basic and Pro configurations provide different levels of temperature control, process automation and endpoint determination, allowing the system to be adapted to routine drying or processes that require controlled shelf heating and programmable methods.

Condenser and vacuum performance

The condenser operates at temperatures down to −55 °C with a specified temperature divergence of ±1.0 °C. Its total capacity and 24-hour condensing capacity are both up to 6 kg. A minimum system vacuum of 0.03 mbar and a controllable range from 0.1 to 1 mbar support sublimation under defined process conditions. The system typically reaches 0.1 mbar within 10 minutes when used with a suitable vacuum configuration.

EcoStream™ technology uses the natural refrigerants R290, R600 and R170. Their GWP value of 3 reduces the climate impact associated with the refrigeration circuit while maintaining the specified condenser performance.

Basic and Pro process control

Basic configurations are intended for drying in flasks, on non-heatable shelves and in trays. Pressure-based endpoint determination helps identify completion of the drying process without relying solely on a fixed run time. The Basic configuration can be selected without vacuum control or with advanced vacuum control.

Pro configurations add programmable methods, advanced vacuum control and heatable shelves with a setting of up to 60 °C and a tolerance of ±1.0 °C. Optional sample temperature sensors and pressure- and temperature-difference tests provide additional process information for determining the endpoints of primary and secondary drying. A sample protective state can activate when the measured sample temperature exceeds the defined collapse temperature.

Infinite-Control™ displays key process parameters graphically in real time, including drying-chamber pressure, sample temperature and shelf temperature where the relevant sensors and heatable shelves are installed. For Pro configurations, the optional Lyovapor™ software supports process monitoring, data logging and report generation.

Drying chambers and sample formats

Manifold racks with 12 or 24 connections allow individual flasks, ampoules and compatible vessels to be connected directly. Top-mounted acrylic chambers can be equipped with four or six shelves, with heatable and non-heatable versions available. Depending on the selected chamber, configurations can also include a manifold top cover or a stoppering cover for closing vials under vacuum.

This modular arrangement supports different container formats without changing the base instrument. It also allows a Lyovapor™ L-210 Basic to be upgraded to a Pro configuration if later workflows require shelf heating, method programming or extended endpoint determination.

Frontloader for large sample batches

The Frontloader is a steel drying chamber with a front-opening PMMA door and large square shelves. The front access facilitates loading and unloading of large sample quantities, Petri dishes, trays, 96-well plates, Deepwell plates and blister packs. With an instrument height of 1.45 m in a trolley-based setup, samples are easy to reach, making loading and unloading comfortable and ergonomic.

Two Frontloader configurations are available:

• Heatable Frontloader: 4 to 6 heatable shelves for use with Lyovapor™ L-210 Pro configurations
• Non-heatable Frontloader: 4 to 12 non-heatable shelves for Basic or Pro configurations

The Frontloader therefore extends the L-210 from top-loaded flask and shelf arrangements to batch workflows that require a larger shelf area or easier handling of wide sample carriers.

Defrosting and installation options

Hot-gas defrosting is available in the Defrosting configurations and accelerates melting of the ice accumulated on the condenser after a run. The base instrument can be installed on a laboratory bench or on the optional trolley.

Model selection guide

Choose Lyovapor™ L-210 Basic for routine freeze-drying in flasks, trays or on non-heatable shelves when shelf-temperature control and programmable drying methods are not required. Select advanced vacuum control if the workflow requires regulated chamber pressure.

Choose Lyovapor™ L-210 Pro when the process requires heat input through controlled shelves, programmable methods, sample-temperature monitoring or combined pressure- and temperature-based endpoint determination. Pro is also the required configuration for a Frontloader with heatable shelves.

Choose a Defrosting configuration when hot-gas defrosting is needed to shorten the post-process melting of ice on the condenser. For high sample volumes, broad carriers or Deepwell plates, select the Frontloader with the shelf type and number appropriate to the required temperature control and batch capacity.

Applications

• Drying and stabilisation of biologically active materials, including peptides, proteins, bacteria, viruses, hormones, enzymes, antibodies and serum
• Pharmaceutical research, formulation and quality-control workflows, including drying in final containers
• Gentle drying of organic and inorganic substances for chemical research and quality control
• Preparation and stabilisation of environmental and pathological samples for analysis or storage
• Drying of foods, beverages, dairy products and natural extracts while preserving temperature-sensitive constituents
• Drying of small quantities in microtitre plates and small flasks, bulk samples in trays and larger batches in 96-well or Deepwell plates

Optional technical data

• Dimensions without drying attachment (W × D × H): 503 × 645 × 510 mm
• Weight: 65.6 kg for Basic; 67.4 kg for Pro
• Minimum clearance: 300 mm on all sides
• Power supply: 200 to 240 VAC ±10%, 50/60 Hz
• Rated power consumption: 1 300 VA for Basic; 1 800 VA for Pro
• Protection rating: IP20
• Noise emission without vacuum pump: < 60 dB(A)
• Operating conditions: indoor use at 5 to 30 °C, up to 2 000 m above sea level and a maximum relative humidity of 80% at temperatures up to 30 °C